Protein name:
Pro-interleukin-16 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax.
Function:
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Subcellular Location:
Isoform 3
Cytoplasm
Nucleus
Protein Attributes:
50:
MESHSRAGKS | RKSAKFRSIS | RSLMLCNAKT | SDDGSSPDEK | YPDPFEISLA |
100:
QGKEGIFHSS | VQLADTSEAG | PSSVPDLALA | SEAAQLQAAG | NDRGKTCRRI |
150:
FFMKESSTAS | SREKPGKLEA | QSSNFLFPKA | CHQRARSNST | SVNPYCTREI |
200:
DFPMTKKSAA | PTDRQPYSLC | SNRKSLSQQL | DCPAGKAAGT | SRPTRSLSTA |
250:
QLVQPSGGLQ | ASVISNIVLM | KGQAKGLGFS | IVGGKDSIYG | PIGIYVKTIF |
300:
AGGAAAADGR | LQEGDEILEL | NGESMAGLTH | QDALQKFKQA | KKGLLTLTVR |
350:
TRLTAPPSLC | SHLSPPLCRS | LSSSTCITKD | SSSFALESPS | APISTAKPNY |
400:
RIMVEVSLQK | EAGVGLGIGL | CSVPYFQCIS | GIFVHTLSPG | SVAHLDGRLR |
450:
CGDEIVEISD | SPVHCLTLNE | VYTILSHCDP | GPVPIIVSRH | PDPQVSEQQL |
500:
KEAVAQAVEN | TKFGKERHQW | SLEGVKRLES | SWHGRPTLEK | EREKNSAPPH |
550:
RRAQKVMIRS | SSDSSYMSGS | PGGSPGSGSA | EKPSSDVDIS | THSPSLPLAR |
600:
EPVVLSIASS | RLPQESPPLP | ESRDSHPPLR | LKKSFEILVR | KPMSSKPKPP |
650:
PRKYFKSDSD | PQKSLEEREN | SSCSSGHTPP | TCGQEARELL | PLLLPQEDTA |
700:
GRSPSASAGC | PGPGIGPQTK | SSTEGEPGWR | RASPVTQTSP | IKHPLLKRQA |
750:
RMDYSFDTTA | EDPWVRISDC | IKNLFSPIMS | ENHGHMPLQP | NASLNEEEGT |
800:
QGHPDGTPPK | LDTANGTPKV | YKSADSSTVK | KGPPVAPKPA | WFRQSLKGLR |
850:
NRASDPRGLP | DPALSTQPAP | ASREHLGSHI | RASSSSSSIR | QRISSFETFG |
900:
SSQLPDKGAQ | RLSLQPSSGE | AAKPLGKHEE | GRFSGLLGRG | AAPTLVPQQP |
950:
EQVLSSGSPA | ASEARDPGVS | ESPPPGRQPN | QKTLPPGPDP | LLRLLSTQAE |
1000:
ESQGPVLKMP | SQRARSFPLT | RSQSCETKLL | DEKTSKLYSI | SSQVSSAVMK |
1050:
SLLCLPSSIS | CAQTPCIPKE | GASPTSSSNE | DSAANGSAET | SALDTGFSLN |
1100:
LSELREYTEG | LTEAKEDDDG | DHSSLQSGQS | VISLLSSEEL | KKLIEEVKVL |
1150:
DEATLKQLDG | IHVTILHKEE | GAGLGFSLAG | GADLENKVIT | VHRVFPNGLA |
1200:
SQEGTIQKGN | EVLSINGKSL | KGTTHHDALA | ILRQAREPRQ | AVIVTRKLTP |
1250:
EAMPDLNSST | DSAASASAAS | DVSVESTAEA | TVCTVTLEKM | SAGLGFSLEG |
1300:
GKGSLHGDKP | LTINRIFKGA | ASEQSETVQP | GDEILQLGGT | AMQGLTRFEA |
1332:
WNIIKALPDG | PVTIVIRRKS | LQSKETTAAG | DS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human Pro-interleukin-16
ELISA Kit for Human Pro-interleukin-16
ELISA Kit for Human Pro-interleukin-16
CLIA Kit for Human Pro-interleukin-16
CLIA Kit for Human Pro-interleukin-16
CLIA Kit for Human Pro-interleukin-16
Polyclonal Antibody for Human Pro-interleukin-16
Polyclonal Antibody for Human Pro-interleukin-16
Polyclonal Antibody for Human Pro-interleukin-16
Monoclonal Antibody for Human Pro-interleukin-16
Monoclonal Antibody for Human Pro-interleukin-16
Monoclonal Antibody for Human Pro-interleukin-16
Protein for Human Pro-interleukin-16
Protein for Human Pro-interleukin-16
Protein for Human Pro-interleukin-16
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
LB Gao, L Rao, YY Wang, et al.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Cerebellum .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 685-1332;VARIANTS GLN-889; LEU-906 AND LYS-1147
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 942-1332
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1203-1332;SUBUNIT
tissue :
Peripheral blood .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1203-1332
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1212-1220;PROTEOLYTIC PROCESSING;MUTAGENESIS OF ASP-1211
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION (PRO-INTERLEUKIN-16);MUTAGENESIS OF 780-LYS-LYS-781 AND 797-LYS--ARG-802
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION;MUTAGENESIS OF SER-743 AND THR-757
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HTLV-1 TAX;SUBCELLULAR LOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION (PRO-INTERLEUKIN-16);SUBCELLULAR LOCATION (PRO-INTERLEUKIN-16);INTERACTION WITH GABPB1 AND HDAC3
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1103-1209